Modulation of glucocorticoid receptor expression, inflammation, and cell apoptosis in septic guinea pig lungs using methylprednisolone.

@article{Kamiyama2008ModulationOG,
  title={Modulation of glucocorticoid receptor expression, inflammation, and cell apoptosis in septic guinea pig lungs using methylprednisolone.},
  author={Koki Kamiyama and Naoyuki Matsuda and Seiji Yamamoto and Ken-ichi Takano and Yasuo Takano and Hiromi Yamazaki and Shun-ichiro Kageyama and Hiroki Yokoo and Takuya Nagata and Noboru Hatakeyama and Kazuhiro Tsukada and Yuichi Hattori},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2008},
  volume={295 6},
  pages={
          L998-L1006
        }
}
The use of glucocorticoids for treatment of sepsis has waxed and waned during the past several decades, and recent randomized controlled trials have evoked a reassessment of this therapy. Most glucocorticoid actions are mediated by its specific intracellular receptors (GRs). Thus we initially evaluated whether sepsis and high-dose corticosteroid therapy can regulate guinea pig pulmonary expression of GRs: active receptor, GRalpha, and dominant negative receptor, GRbeta. Sepsis induction by LPS… CONTINUE READING

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