Modulation of glucocorticoid receptor phosphorylation and transcriptional activity by a C-terminal-associated protein phosphatase.

@article{Wang2007ModulationOG,
  title={Modulation of glucocorticoid receptor phosphorylation and transcriptional activity by a C-terminal-associated protein phosphatase.},
  author={Zhen Hua Wang and Weiwei Chen and Evelyn A Kono and Thoa Dang and Michael J Garabedian},
  journal={Molecular endocrinology},
  year={2007},
  volume={21 3},
  pages={625-34}
}
The glucocorticoid receptor (GR) is phosphorylated at three major sites on its N terminus (S203, S211, and S226), and phosphorylation modulates GR-regulatory functions in vivo. We examined the phosphorylation site interdependence, the contribution of the receptor C-terminal ligand-binding domain, and the participation of protein phosphatases in GR N-terminal phosphorylation and gene expression. We found that GR phosphorylation at S203 was greater when S226 was not phosphorylated and vice versa… CONTINUE READING

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