Modulation of gene expression in U251 glioblastoma cells by binding of mutant p53 R273H to intronic and intergenic sequences

@inproceedings{Brzdov2009ModulationOG,
  title={Modulation of gene expression in U251 glioblastoma cells by binding of mutant p53 R273H to intronic and intergenic sequences},
  author={Marie Br{\'a}zdov{\'a} and Timo Quante and Lars T{\"o}gel and Korden Walter and Christine E. Loscher and Vlastimil Tich{\'y} and Lenka {\vC}in{\vc}{\'a}rov{\'a} and Wolfgang Deppert and Genrich V. Tolstonog},
  booktitle={Nucleic acids research},
  year={2009}
}
Missense point mutations in the TP53 gene are frequent genetic alterations in human tumor tissue and cell lines derived thereof. Mutant p53 (mutp53) proteins have lost sequence-specific DNA binding, but have retained the ability to interact in a structure-selective manner with non-B DNA and to act as regulators of transcription. To identify functional… CONTINUE READING