Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival.

@article{Kwak2003ModulationOG,
  title={Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival.},
  author={M K Kwak and Nobunao Wakabayashi and Ken Itoh and Hozumi Motohashi and Masayuki Yamamoto and Thomas Wells Kensler},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 10},
  pages={8135-45}
}
Enzyme inducers such as 3H-1,2-dithiole-3-thione (D3T) enhance the detoxication of environmental carcinogens and protect against neoplasia. The putative molecular sensor for inducers is Keap1, a sulfhydryl-rich protein that sequesters the transcription factor Nrf2 in the cytoplasm. Expression of these detoxication enzymes is blunted in nrf2-deficient mice; moreover, these mice are more sensitive to carcinogenesis, and the protective actions of dithiolethiones are lost with nrf2 disruption… CONTINUE READING
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