• Corpus ID: 12863372

Modulation of gastric mucosal calcium channel activity by sucralfate.

@article{Slomiany1992ModulationOG,
  title={Modulation of gastric mucosal calcium channel activity by sucralfate.},
  author={B. L. Slomiany and Jianping Liu and Amalia Slomiany},
  journal={Biochemistry international},
  year={1992},
  volume={28 6},
  pages={
          1125-34
        }
}
A gastric mucosal calcium channel complex was isolated from solubilized epithelial cell membranes by affinity chromatography on wheat germ agglutinin. The complex following reconstitution into phosphatidylcholine vesicles exhibited an active 45Ca2+ uptake and responded to calcium channel activator, BAY K8644, and the antagonist, PN200-110. The uptake of 45Ca2+ was inhibited by an antiulcer agent, sucralfate, which at 100 micrograms/ml evoked maximal inhibitory effect of 52%. The channel complex… 
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