Modulation of gastric emptying and gastrointestinal transit in rats through intestinal cannabinoid CB(1) receptors.

@article{Landi2002ModulationOG,
  title={Modulation of gastric emptying and gastrointestinal transit in rats through intestinal cannabinoid CB(1) receptors.},
  author={Marco Landi and Tiziano Croci and Murielle Rinaldi-Carmona and J Maffrand and G{\'e}rard Le Fur and Luciano Manara},
  journal={European journal of pharmacology},
  year={2002},
  volume={450 1},
  pages={77-83}
}
We studied the delay in gastric emptying and gastrointestinal transit induced by the cannabinoid receptor agonists (+)-WIN 55,212-2 (R(+)-[2,3-dihydro-5-methyl-3-[(4-morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazin-yl]-(1-naphthalenyl)methanone mesylate) and CP 55,940 ((-)-cis-3[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(3-hydroxypropyl) cyclohexanol), as prevented by the selective cannabinoid CB(1)-receptor antagonist SR141716 ((N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4… CONTINUE READING

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