Modulation of ganglioside expression in human melanoma cell lines; increased resistance to chemo- and radiation treatment.

@article{Kunitomo1992ModulationOG,
  title={Modulation of ganglioside expression in human melanoma cell lines; increased resistance to chemo- and radiation treatment.},
  author={Kazufumi Kunitomo and Reiko F. Irie and David H. Kern},
  journal={The Tokushima journal of experimental medicine},
  year={1992},
  volume={39 1-2},
  pages={55-62}
}
Cell surface gangliosides in human melanoma cell lines were modulated by pretreatment and adaptation to 6-thioguanine and 5-bromo-deoxyuridine. Chemo- and radiation sensitivities were compared in original cell lines and modulated cells by the human tumor colony-forming assay. Modulated cells showed decreased expression of cell surface GM2 and GD2 gangliosides. This reduction was correlated with increased resistance to bleomycin, vincristine, cisplatin and radiation treatment. These results… CONTINUE READING