Corpus ID: 25882385

Modulation of gamma-aminobutyric acid receptor-channel complex by alcohols.

  title={Modulation of gamma-aminobutyric acid receptor-channel complex by alcohols.},
  author={Masanobu Nakahiro and Osamu Arakawa and Toshio Narahashi},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={259 1},
The electrophysiological effects of ethanol on the gamma-aminobutyric acid (GABA) system have been a matter of controversies; some observed an enhancement of GABA response whereas others failed to see the effect. Acute effects of n-alcohols (ethanol, n-butanol, n-hexanol and n-octanol) on chloride current activated by bath application of GABA were studied with the rat dorsal root ganglion neurons maintained in primary culture. The whole-cell patch-clamp technique was used to record the current… Expand
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