Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: evidence in terms of response rate. Advanced Colorectal Cancer Meta-Analysis Project.

@article{1992ModulationOF,
  title={Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: evidence in terms of response rate. Advanced Colorectal Cancer Meta-Analysis Project.},
  author={},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={1992},
  volume={10 6},
  pages={896-903}
}
  • Published 1992 in
    Journal of clinical oncology : official journal…
PURPOSE A meta-analysis was performed on nine randomized clinical trials that compared fluorouracil (5-FU) with 5-FU plus intravenous (IV) leucovorin (LV) for the treatment of advanced colorectal cancer. DESIGN The analysis was based on the most recently updated individual patient data from all trials. The end points of interest were tumor response and overall survival. RESULTS Therapy with 5-FU plus LV administered either as weekly or monthly regimens showed a highly significant benefit… CONTINUE READING