Modulation of fluoropyrimidine metabolism in L1210 cells by L-alanosine.

@article{Heimer1983ModulationOF,
  title={Modulation of fluoropyrimidine metabolism in L1210 cells by L-alanosine.},
  author={Robert Heimer and D Goldberg and Edwin C. Cadman},
  journal={Biochemical pharmacology},
  year={1983},
  volume={32 2},
  pages={
          199-206
        }
}
L-Alanosine, an analogue of aspartic acid which inhibits the conversion of inosine monophosphate to adenosine monophosphate (AMP), was evaluated in L1210 cells as a modulator of 5-fluorouracil (FUra) and 5-fluorouridine (FUrd) metabolism. L-Alanosine resulted in increased intra-cellular levels of 5-phosphoribosyl-1-pyrophosphate (PRPP), enhanced FUra metabolism to ribonucleotide derivatives, and resulted in more FUra residues incorporated into RNA. Sequential addition of L-alanosine and FUra… Expand
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