Modulation of fibroblastic cytoskeletal features during pathological situations: the role of extracellular matrix and cytokines.

@article{Desmoulire1994ModulationOF,
  title={Modulation of fibroblastic cytoskeletal features during pathological situations: the role of extracellular matrix and cytokines.},
  author={Alexis Desmouli{\`e}re and Giulio Gabbiani},
  journal={Cell motility and the cytoskeleton},
  year={1994},
  volume={29 3},
  pages={
          195-203
        }
}
During the healing of an open wound, fibroblasts gradually become the main cellular elements of granulation tissue [Martinez-Hernandez, 19881, acquire morphological and biochemical features of smooth muscle (SM) cells, including the expression of a-SM actin, the actin isoform typical of vascular SM cells, and have been called myofibroblasts; they eventually disappear when granulation tissue evolves into a scar. Myofibroblasts persist in excessive scarring (hypertrophic scar) and in fibrotic… CONTINUE READING
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