Modulation of fibroblast growth factor-2 receptor binding, signaling, and mitogenic activity by heparin-mimicking polysulfonated compounds.

@article{Liekens1999ModulationOF,
  title={Modulation of fibroblast growth factor-2 receptor binding, signaling, and mitogenic activity by heparin-mimicking polysulfonated compounds.},
  author={Sandra Liekens and Daria Leali and Johan Neyts and Robert Esnouf and Marco Rusnati and Patrizia Dell'era and Prabhat C. Maudgal and Erik de Clercq and Marco Presta},
  journal={Molecular pharmacology},
  year={1999},
  volume={56 1},
  pages={204-13}
}
Basic fibroblast growth factor (FGF-2) interacts with high-affinity tyrosine-kinase fibroblast growth factor receptors (FGFRs) and low-affinity heparan sulfate proteoglycans (HSPGs) in target cells. Both interactions are required for FGF-2-mediated biological responses. Here we report the FGF-2 antagonist activity of novel synthetic sulfonic acid polymers with distinct chemical structures and molecular masses (MMs). PAMPS [poly(2-acrylamido-2-methyl-1-propanesulfonic acid)], (MM approximately 7… CONTINUE READING