Modulation of feline immunodeficiency virus infection by stromal cell-derived factor.

@article{Hosie1998ModulationOF,
  title={Modulation of feline immunodeficiency virus infection by stromal cell-derived factor.},
  author={Margaret J. Hosie and Nellie Broere and Joseph Hesselgesser and Julie Davis Turner and James A Hoxie and James C Neil and Brian J. Willett},
  journal={Journal of virology},
  year={1998},
  volume={72 3},
  pages={2097-104}
}
The alpha-chemokine receptor CXCR4 has recently been shown to support syncytium formation mediated by strains of feline immunodeficiency virus (FIV) that have been selected for growth in the Crandell feline kidney cell line (CrFK-tropic virus). Given that both human and feline CXCR4 support syncytium formation mediated by FIV, we investigated whether human stromal cell-derived factor (SDF-1) would inhibit infection with FIV. Human SDF-1alpha and SDF-1beta bound with a high affinity (K(D)s of 12… CONTINUE READING

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