Modulation of extracellular glutamate concentration in rat brain slices by cystine-glutamate exchange.

@article{Warr1999ModulationOE,
  title={Modulation of extracellular glutamate concentration in rat brain slices by cystine-glutamate exchange.},
  author={O Warr and Masami Takahashi and David Attwell},
  journal={The Journal of physiology},
  year={1999},
  volume={514 ( Pt 3)},
  pages={783-93}
}
1. The role of cystine-glutamate exchange in controlling the extracellular glutamate concentration in the central nervous system was examined by whole-cell clamping neurons in rat brain slices, and using their glutamate receptors as sensors of extracellular glutamate concentration. 2. Applying cystine to cerebellar slices generated a membrane current in Purkinje cells which was abolished by glutamate receptor blockers. Similar cystine-evoked currents were seen in pyramidal cells of frontal… CONTINUE READING

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