Modulation of expression of the ToxR regulon in Vibrio cholerae by a member of the two-component family of response regulators.

@article{Wong1998ModulationOE,
  title={Modulation of expression of the ToxR regulon in Vibrio cholerae by a member of the two-component family of response regulators.},
  author={Sandy M. S. Wong and P A Carroll and Laurence G Rahme and Frederick M. Ausubel and Stephen B. Calderwood},
  journal={Infection and immunity},
  year={1998},
  volume={66 12},
  pages={5854-61}
}
The ToxRS system in Vibrio cholerae plays a central role in the modulation of virulence gene expression in response to environmental stimuli. An integration of multiple signalling inputs mediated by ToxR, -S, and -T controls virulence gene expression leading to cholera toxin (CT) production. Recently, we identified a new virulence locus, varA (virulence associated regulator), in classical V. cholerae O1 that positively controls transcription of tcpA, the major subunit of the toxin-coregulated… CONTINUE READING

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