Modulation of expression and activity of intestinal multidrug resistance-associated protein 2 by xenobiotics.

@article{Tocchetti2016ModulationOE,
  title={Modulation of expression and activity of intestinal multidrug resistance-associated protein 2 by xenobiotics.},
  author={Guillermo Nicol{\'a}s Tocchetti and Juan Pablo Rigalli and Maite Roc{\'i}o Arana and Silvina Stella Maris Villanueva and Aldo Domingo Mottino},
  journal={Toxicology and applied pharmacology},
  year={2016},
  volume={303},
  pages={45-57}
}
The multidrug resistance-associated protein 2 (MRP2/ABCC2) is a transporter that belongs to the ATP-binding cassette (ABC) superfamily. In the intestine, it is localized to the apical membrane of the enterocyte and plays a key role in limiting the absorption of xenobiotics incorporated orally. MRP2 may also play a role in systemic clearance of xenobiotics available from the serosal side of the intestine. MRP2 transports a wide range of substrates, mainly organic anions conjugated with… CONTINUE READING

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