Modulation of exon skipping by high-affinity hnRNP A1-binding sites and by intron elements that repress splice site utilization.

@article{Blanchette1999ModulationOE,
  title={Modulation of exon skipping by high-affinity hnRNP A1-binding sites and by intron elements that repress splice site utilization.},
  author={Marco Blanchette and Benoit Chabot},
  journal={The EMBO journal},
  year={1999},
  volume={18 7},
  pages={1939-52}
}
The RNA-binding protein hnRNP A1 is a splicing regulator produced by exclusion of alternative exon 7B from the A1 pre-mRNA. Each intron flanking exon 7B contains a high-affinity A1-binding site. The A1-binding elements promote exon skipping in vivo, activate distal 5' splice site selection in vitro and improve the responsiveness of pre-mRNAs to increases in the concentration of A1. Whereas the glycine-rich C-terminal domain of A1 is not required for binding, it is essential to activate the… CONTINUE READING
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