Modulation of evoked contractions in rat arteries by ryanodine, thapsigargin, and cyclopiazonic acid.

@article{Shima1992ModulationOE,
  title={Modulation of evoked contractions in rat arteries by ryanodine, thapsigargin, and cyclopiazonic acid.},
  author={Hiroki Shima and Mordecai P. Blaustein},
  journal={Circulation research},
  year={1992},
  volume={70 5},
  pages={968-77}
}
The contribution of sarcoplasmic reticulum (SR) Ca2+ release to evoked tension in rat arterial rings was studied by comparing the effects of ryanodine (an SR Ca2+ channel opener) and thapsigargin and cyclopiazonic acid (CPA) (two Ca(2+)-ATPase inhibitors). Isometric tension was evoked by serotonin (5-HT), 30-50 mM external K+, and 10 mM caffeine in rings of aorta and a small (second-order) branch of the superior mesenteric artery (SMA). Resting tension was unaffected by 10 microM ryanodine or 1… CONTINUE READING

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