Modulation of ethanol drinking-in-the-dark by mecamylamine and nicotinic acetylcholine receptor agonists in C57BL/6J mice

@article{Hendrickson2009ModulationOE,
  title={Modulation of ethanol drinking-in-the-dark by mecamylamine and nicotinic acetylcholine receptor agonists in C57BL/6J mice},
  author={Linzy M. Hendrickson and Rubing Zhao-Shea and Andrew R. Tapper},
  journal={Psychopharmacology},
  year={2009},
  volume={204},
  pages={563-572}
}
RationaleRecent reports describe a restricted access ethanol consumption paradigm where C57Bl/6J mice drink until intoxicated. Termed “drinking in the dark” (DID), this paradigm has been used as a model of binge drinking. Although neuronal nicotinic acetylcholine receptors (nAChRs) have been implicated in alcohol drinking in rats pre-trained to self-administer ethanol, their role in binge-like ethanol consumption is unknown.ObjectivesTo determine if nAChRs are involved in binge drinking as… 

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