Modulation of ethanol drinking-in-the-dark by mecamylamine and nicotinic acetylcholine receptor agonists in C57BL/6J mice

Linzy M. Hendrickson; Rubing Zhao-Shea; Andrew R Tapper

@article{Hendrickson2009ModulationOE, title={Modulation of ethanol drinking-in-the-dark by mecamylamine and nicotinic acetylcholine receptor agonists in C57BL/6J mice}, author={Linzy M. Hendrickson and Rubing Zhao-Shea and Andrew R Tapper}, journal={Psychopharmacology}, year={2009}, volume={204}, pages={563-572} }

Recent reports describe a restricted access ethanol consumption paradigm where C57Bl/6J mice drink until intoxicated. Termed “drinking in the dark” (DID), this paradigm has been used as a model of binge drinking. Although neuronal nicotinic acetylcholine receptors (nAChRs) have been implicated in alcohol drinking in rats pre-trained to self-administer ethanol, their role in binge-like ethanol consumption is unknown. To determine if nAChRs are involved in binge drinking as measured by the DID… CONTINUE READING

Ethanol actions on multiple ion channels: which are important?

R. Adron Harris
Alcoholism, clinical and experimental research
1999

Modulation of ethanol drinking-in-the-dark by mecamylamine and nicotinic acetylcholine receptor agonists in C57BL/6J mice

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Lobeline and cytisine reduce voluntary ethanol drinking behavior in male C57BL/6J mice.

Differential regulation of alcohol taking and seeking by antagonism at α4β2 and α3β4 nAChRs

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Effect of single‐nucleotide polymorphisms in ADH1B,ADH4,ADH1C,OPRM1,DRD2,BDNF, and ALDH2 genes on alcohol dependence in a Caucasian population

Nicotine enhances alcohol intake and dopaminergic responses through β2* and β4* nicotinic acetylcholine receptors

No evidence of a role of the β4 subunit of the nicotinic acetylcholine receptor in alcohol-related behaviors

Different Hypothalamic Nicotinic α7 Receptor Expression and Response to Low Nicotine Dose in Alcohol-Preferring and Alcohol-Avoiding Rats.

Exposure to nicotine increases nicotinic acetylcholine receptor density in the reward pathway and binge ethanol consumption in C57BL/6J adolescent female mice.

References

Subunit composition and pharmacology of two classes of striatal presynaptic nicotinic acetylcholine receptors mediating dopamine release in mice.

Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking.

Mecamylamine: new therapeutic uses and toxicity/risk profile.

Involvement of nicotinic receptors in alcohol self-administration.

Ethanol actions on multiple ion channels: which are important?

Voluntary ethanol intake in the rat: effects of nicotinic acetylcholine receptor blockade or subchronic nicotine treatment.

Mecamylamine is a selective non-competitive antagonist of N-methyl-D-aspartate- and aspartate-induced currents in horizontal cells dissociated from the catfish retina.

Mecamylamine prevents neuronal apoptosis induced by glutamate and low potassium via differential anticholinergic-independent mechanisms.

Acute effects of Naltrexone and GBR 12909 on ethanol drinking-in-the-dark in C57BL/6J mice

Cytisine, a partial agonist of high-affinity nicotinic acetylcholine receptors, has antidepressant-like properties in male C57BL/6J mice.

Modulation of ethanol drinking-in-the-dark by mecamylamine and nicotinic acetylcholine receptor agonists in C57BL/6J mice

6 Figures & Tables

Topics

Cited By

Lobeline and cytisine reduce voluntary ethanol drinking behavior in male C57BL/6J mice.

Differential regulation of alcohol taking and seeking by antagonism at α4β2 and α3β4 nAChRs

Varenicline and cytisine: two nicotinic acetylcholine receptor ligands reduce ethanol intake in University of Chile bibulous rats

Modulation of ethanol consumption by genetic and pharmacological manipulation of nicotinic acetylcholine receptors in mice

Dopamine Receptors Differentially Control Binge Alcohol Drinking-Mediated Synaptic Plasticity of the Core Nucleus Accumbens Direct and Indirect Pathways.

Effect of single‐nucleotide polymorphisms in ADH1B,ADH4,ADH1C,OPRM1,DRD2,BDNF, and ALDH2 genes on alcohol dependence in a Caucasian population

Nicotine enhances alcohol intake and dopaminergic responses through β2* and β4* nicotinic acetylcholine receptors

No evidence of a role of the β4 subunit of the nicotinic acetylcholine receptor in alcohol-related behaviors

Different Hypothalamic Nicotinic α7 Receptor Expression and Response to Low Nicotine Dose in Alcohol-Preferring and Alcohol-Avoiding Rats.

Exposure to nicotine increases nicotinic acetylcholine receptor density in the reward pathway and binge ethanol consumption in C57BL/6J adolescent female mice.

References

Subunit composition and pharmacology of two classes of striatal presynaptic nicotinic acetylcholine receptors mediating dopamine release in mice.

Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking.

Mecamylamine: new therapeutic uses and toxicity/risk profile.

Involvement of nicotinic receptors in alcohol self-administration.

Ethanol actions on multiple ion channels: which are important?

Voluntary ethanol intake in the rat: effects of nicotinic acetylcholine receptor blockade or subchronic nicotine treatment.

Mecamylamine is a selective non-competitive antagonist of N-methyl-D-aspartate- and aspartate-induced currents in horizontal cells dissociated from the catfish retina.

Mecamylamine prevents neuronal apoptosis induced by glutamate and low potassium via differential anticholinergic-independent mechanisms.

Acute effects of Naltrexone and GBR 12909 on ethanol drinking-in-the-dark in C57BL/6J mice

Cytisine, a partial agonist of high-affinity nicotinic acetylcholine receptors, has antidepressant-like properties in male C57BL/6J mice.

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