Modulation of ethanol drinking-in-the-dark by mecamylamine and nicotinic acetylcholine receptor agonists in C57BL/6J mice
@article{Hendrickson2009ModulationOE, title={Modulation of ethanol drinking-in-the-dark by mecamylamine and nicotinic acetylcholine receptor agonists in C57BL/6J mice}, author={Linzy M. Hendrickson and Rubing Zhao-Shea and Andrew R. Tapper}, journal={Psychopharmacology}, year={2009}, volume={204}, pages={563-572} }
RationaleRecent reports describe a restricted access ethanol consumption paradigm where C57Bl/6J mice drink until intoxicated. Termed “drinking in the dark” (DID), this paradigm has been used as a model of binge drinking. Although neuronal nicotinic acetylcholine receptors (nAChRs) have been implicated in alcohol drinking in rats pre-trained to self-administer ethanol, their role in binge-like ethanol consumption is unknown.ObjectivesTo determine if nAChRs are involved in binge drinking as…
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