Modulation of estrogen receptor activity by selective coregulators

@article{Martini2003ModulationOE,
  title={Modulation of estrogen receptor activity by selective coregulators},
  author={Paolo G. V. Martini and Benita S. Katzenellenbogen},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2003},
  volume={85},
  pages={117-122}
}
The estrogen receptor (ER), a member of the nuclear hormone receptor superfamily, is a hormone-regulated transcription factor that mediates the effects of estrogens and antiestrogens in breast cancer and other estrogen target cells. Because of the role of estrogens in promoting the growth and progression of breast cancer, there is great interest in exploring ways to functionally inactivate the ER, thereby suppressing ER-mediated gene expression and cell proliferation. These approaches have… Expand
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