Modulation of erythrocyte-endothelial interactions and the vasocclusive severity of sickling disorders.

@article{Hebbel1981ModulationOE,
  title={Modulation of erythrocyte-endothelial interactions and the vasocclusive severity of sickling disorders.},
  author={Robert P. Hebbel and Charles F. Moldow and Martin H Steinberg},
  journal={Blood},
  year={1981},
  volume={58 5},
  pages={
          947-52
        }
}
The abnormal adherence of sickle erythrocytes to cultured human vascular endothelium varies among patients and correlates with vasocclusive severity within and among the different sickling disorders. For individual patients, the development of an acute vasocclusive event is not accompanied by an increase in the inherent propensity for their erythrocytes to adhere to endothelium. However, the onset of vasocclusion appears to be associated with the appearance of plasma factors, such as fibrinogen… CONTINUE READING

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