Modulation of eotaxin formation and eosinophil migration by selective inhibitors of phosphodiesterase type 4 isoenzyme.

@article{Silva2001ModulationOE,
  title={Modulation of eotaxin formation and eosinophil migration by selective inhibitors of phosphodiesterase type 4 isoenzyme.},
  author={Patricia M.R. Silva and Andr{\'e}a Cat{\~a}o Alves and Magda Fr{\'a}guas Serra and Ana L{\'u}cia Pires and Jose Denison Prado Silva and Emiliano de Oliveira Barreto and Renato S B Cordeiro and Peter J. Jose and Mauro M Teixeira and Vincent Lagente and Marco Aur{\'e}lio Martins},
  journal={British journal of pharmacology},
  year={2001},
  volume={134 2},
  pages={283-94}
}
1. This study was undertaken to investigate the possible contribution of the blockade of eotaxin generation to the anti-eosinophilotactic effect of phosphodiesterase (PDE) type 4 inhibitors. In some experiments, the putative synergistic interaction between PDE type 4 inhibitors and the beta2-agonist salbutamol was also assessed. 2. Sensitized guinea-pigs aerosolized with antigen (5% ovalbumin, OVA) responded with a significant increase in eotaxin and eosinophil levels in the bronchoalveolar… CONTINUE READING
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