Modulation of eomes activity alters the size of the developing heart: implications for in utero cardiac gene therapy.

@article{Ryan2004ModulationOE,
  title={Modulation of eomes activity alters the size of the developing heart: implications for in utero cardiac gene therapy.},
  author={Kenneth C Ryan and Andreas P. Russ and Robert J. Levy and David J Wehr and Jingtao You and Mathew C. Easterday},
  journal={Human gene therapy},
  year={2004},
  volume={15 9},
  pages={
          842-55
        }
}
Congenital heart disease is the most prevalent cause of infant morbidity and mortality in developed countries. The mechanisms responsible for many specific types of congenital cardiac malformations are strongly associated with gene abnormalities. However, at this time no strategies for gene therapy of the various congenital heart malformations have been investigated. In the present studies we focus on Eomesodermin (Eomes), a T-box transcription factor expressed in developing vertebrate mesoderm… CONTINUE READING

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