Modulation of energy deficiency in Huntington's disease via activation of the peroxisome proliferator-activated receptor gamma.

@article{Chiang2010ModulationOE,
  title={Modulation of energy deficiency in Huntington's disease via activation of the peroxisome proliferator-activated receptor gamma.},
  author={Ming-Chang Chiang and Chiung-Mei Chen and M R Lee and Hsiao-Wen Chen and Hui-mei Chen and Yu-Shuo Wu and Cheng-Han Hung and Jheng-Jie Kang and Ching-Pang Chang and Chen -Nen Chang and Yih-Ru Wu and Yau-Sheng Tsai and Yijuang Chern},
  journal={Human molecular genetics},
  year={2010},
  volume={19 20},
  pages={4043-58}
}
Huntington's disease (HD) is a neurodegenerative disease caused by the expansion of a CAG trinucleotide repeat in exon 1 of the huntingtin (HTT) gene. Here, we report that the transcript of the peroxisome proliferator-activated receptor-γ (PPARγ), a transcription factor that is critical for energy homeostasis, was markedly downregulated in multiple tissues of a mouse model (R6/2) of HD and in lymphocytes of HD patients. Therefore, downregulation of PPARγ seems to be a pathomechanism of HD… CONTINUE READING

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