Modulation of endotoxin-stimulated TNF-α gene expression by ketamine and propofol in cultured human whole blood

Abstract

Aim. Anesthetic agents have direct and indirect effects on immunocompetent cells but the molecular mechanisms of direct interactions are largely unknown. Therefore, the effect of propofol and ketamine on TNF-α gene expression was studied in cultured blood from healthy volunteers. Methods. TNF-α was measured in blood cultured in the absence or presence of… (More)
DOI: 10.1007/s001010100149

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