Modulation of endothelial inward-rectifier K+ current by optical isomers of cholesterol.

Abstract

Membrane potential of aortic endothelial cells under resting conditions is dominated by inward-rectifier K(+) channels belonging to the Kir 2 family. Regulation of endothelial Kir by membrane cholesterol was studied in bovine aortic endothelial cells by altering the sterol composition of the cell membrane. Our results show that enriching the cells with… (More)

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@article{Romanenko2002ModulationOE, title={Modulation of endothelial inward-rectifier K+ current by optical isomers of cholesterol.}, author={Victor Romanenko and George H. Rothblat and Irena Levitan}, journal={Biophysical journal}, year={2002}, volume={83 6}, pages={3211-22} }