Modulation of endogenous osteogenic protein-1 (OP-1) by interleukin-1 in adult human articular cartilage.

  title={Modulation of endogenous osteogenic protein-1 (OP-1) by interleukin-1 in adult human articular cartilage.},
  author={Charis A Merrihew and Stephan Soeder and David C. Rueger and Klaus E. Kuettner and Susan Chubinskaya},
  journal={The Journal of bone and joint surgery. American volume},
  volume={85-A Suppl 3},
BACKGROUND Osteogenic protein-1 (OP-1, BMP-7) induces bone formation and cartilage growth. Since OP-1 is an anabolic factor expressed by human articular chondrocytes, we examined the response of endogenous OP-1 to interleukin-1beta (IL-1beta) in human articular cartilage. METHODS Normal adult human articular cartilage explants were cultured for twenty-five days in the presence of medium only or were treated with a low dose (0.1 ng/mL) or high dose (1.0 ng/mL) of IL-1beta for forty-eight or… CONTINUE READING


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