Modulation of endogenous VEGF-A expression under hypoxia by using artificial transcription factors.

@article{Mori2008ModulationOE,
  title={Modulation of endogenous VEGF-A expression under hypoxia by using artificial transcription factors.},
  author={Tomoaki Mori and Jun Sasaki and Yasuhiro Aoyama and Takashi Sera},
  journal={Nucleic acids symposium series},
  year={2008},
  volume={52},
  pages={187-8}
}
The vascular endothelial growth factor A (VEGF-A) gene is an attractive therapeutic target because both activation and repression of the gene are useful for treatment or cure of many diseases related to abnormal angiogenesis. To modulate the endogenous gene expression artificially, we previously designed a six-finger AZP to recognize a 19-bp DNA in the VEGF-A gene, and fused the AZP with a nuclear localization signal and a repressor domain to generate an artificial transcription factor (ATF… CONTINUE READING

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