Modulation of emesis by fentanyl and opioid receptor antagonists in Suncus murinus (house musk shrew).

Abstract

The anti-emetic mechanism of action of fentanyl to inhibit nicotine (5 mg/kg, s.c.)-induced emesis was investigated in Suncus murinus. The anti-emetic action of fentanyl (40 microg/kg, s.c.) was antagonised by the opioid receptor antagonists naltrexone (1 mg/kg, s.c.), naloxone (1 mg/kg, s.c.), M8008 (16S-methylcyprenorphine; 1 mg/kg, s.c.) and MR 2266 (5,9… (More)

Topics

Cite this paper

@article{Rudd1999ModulationOE, title={Modulation of emesis by fentanyl and opioid receptor antagonists in Suncus murinus (house musk shrew).}, author={John Anthony Rudd and C. H. Cheng and Randy Naylor and M P Ngan and Malts Wai}, journal={European journal of pharmacology}, year={1999}, volume={374 1}, pages={77-84} }