Modulation of drug-linker design to enhance in vivo potency of homogeneous antibody-drug conjugates.

@article{Pabst2017ModulationOD,
  title={Modulation of drug-linker design to enhance in vivo potency of homogeneous antibody-drug conjugates.},
  author={Martin Pabst and William McDowell and Ana{\"i}s Manin and Andrew F. Kyle and Nicolas Camper and Elena De Juan and Vimal Parekh and Felicity Rudge and Hiteshri Makwana and Terrence Kantner and Hemal Parekh and Aurelie Michelet and XiaoBo Sheng and Gina Popa and Carolyn Tucker and Farzad Khayrzad and Derek R Pollard and Katarzyna Kozakowska and Ricardo Resende and Alan Jenkins and F{\'a}bio Fonseca Sim{\~o}es and Dave Morris and Paul Williams and George O. Badescu and Matthew P. Baker and Matthew Bird and M. J. Frigerio and Antony Godwin},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2017},
  volume={253},
  pages={160-164}
}
Antibody-drug conjugates (ADCs) are a promising class of anticancer agents which have undergone substantial development over the past decade and are now achieving clinical success. The development of novel site-specific conjugation technologies enables the systematic study of architectural features within the antibody conjugated drug linker that may affect overall therapeutic indices. Here we describe the results of a systematic study investigating the impact of drug-linker design on the in… CONTINUE READING
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