Modulation of dopamine transporter function by α‐synuclein is altered by impairment of cell adhesion and by induction of oxidative stress

@article{Wersinger2003ModulationOD,
  title={Modulation of dopamine transporter function by $\alpha$‐synuclein is altered by impairment of cell adhesion and by induction of oxidative stress},
  author={Christophe Wersinger and Delphine Prou and Philippe Vernier and Anita Sidhu},
  journal={The FASEB Journal},
  year={2003},
  volume={17}
}
Human α‐synuclein accumulates in dopaminergic neurons as intraneuronal inclusions, Lewy bodies, which are characteristic of idiopathic Parkinson's disease (PD). Here, we suggest that modulation of the functional activity of the dopamine transporter (DAT) by α‐synuclein may be a key factor in the preferential degeneration of mesencephalic dopamine (DA)‐synthesizing neurons in PD. In cotransfected Ltk‐, HEK 293, and SK‐N‐MC cells, α‐synuclein induced a 35% decrease in [3H]DA uptake. Biotinylated… 

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...

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  • Ji-Heui SeoJ. Rah Y. Suh
  • Biology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2002
It is shown that α‐SN plays dual roles of neuroprotection and neurotoxicity depending on its concentration or level of expression, and at nanomolar concentrations, α‐ SN protected neurons against serum deprivation, oxidative stress, and excitotoxicity through the PI3/Akt signaling pathway.
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