Modulation of dopamine release in the striatum by physiologically relevant levels of nicotine.

  title={Modulation of dopamine release in the striatum by physiologically relevant levels of nicotine.},
  author={Li Wang and Shujiang Shang and Xinjiang Kang and Sasa Teng and Feipeng Zhu and Bin Liu and Qihui Wu and Mingli Li and Wei Liu and Huadong Xu and Li Zhou and Ruiying Jiao and Haiqiang Dou and Panli Zuo and Xiaoyu Zhang and Lianghong Zheng and Shirong Wang and Changhe Wang and Zhuan Zhou},
  journal={Nature communications},
Striatal dopamine (DA) release can be independently triggered not only by action potentials (APs) in dopaminergic axons but also APs in cholinergic interneurons (ChIs). Nicotine causes addiction by modulating DA release, but with paradoxical findings. Here, we investigate how physiologically relevant levels of nicotine modulate striatal DA release. The optogenetic stimulation of ChIs elicits DA release, which is potently inhibited by nicotine with an IC50 of 28 nM in the dorsal striatum slice… CONTINUE READING
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The authors declare no competing financial interests

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