Modulation of dopamine release in the striatum by physiologically relevant levels of nicotine.

@article{Wang2014ModulationOD,
  title={Modulation of dopamine release in the striatum by physiologically relevant levels of nicotine.},
  author={Li Wang and Shujiang Shang and Xinjiang Kang and Sasa Teng and Feipeng Zhu and Bin Liu and Qihui Wu and Mingli Li and Wei Liu and Huadong Xu and Li Zhou and Ruiying Jiao and Haiqiang Dou and Panli Zuo and Xiaoyu Zhang and Lianghong Zheng and Shirong Wang and Changhe Wang and Zhuan Zhou},
  journal={Nature communications},
  year={2014},
  volume={5},
  pages={3925}
}
Striatal dopamine (DA) release can be independently triggered not only by action potentials (APs) in dopaminergic axons but also APs in cholinergic interneurons (ChIs). Nicotine causes addiction by modulating DA release, but with paradoxical findings. Here, we investigate how physiologically relevant levels of nicotine modulate striatal DA release. The optogenetic stimulation of ChIs elicits DA release, which is potently inhibited by nicotine with an IC50 of 28 nM in the dorsal striatum slice… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 5 times over the past 90 days. VIEW TWEETS
11 Citations
49 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 49 references

The authors declare no competing financial interests

  • R. L. Papke, P. R. Sanberg, +25 authors C. W. wrote the paper. Additional information Competi interests
  • Reprints and permission information is available…
  • 2014

Temporal components of a synaptic terminal-terminal transmission in dorsal striatum slices

  • L Wang
  • Society for Neuroscience,
  • 2013

alpha6* nicotinic acetylcholine receptor expression and function in a visual salience circuit

  • Mackey, D E.
  • J. Neurosci
  • 2012

setting the tone for reward processing

  • Cachope, R. et al. Selective activation of cholinergic interne release
  • Cell Rep. 2, 33–41
  • 2012

Similar Papers

Loading similar papers…