Modulation of differentiation and mineralization of marrow stromal cells cultured on biomimetic hydrogels modified with Arg-Gly-Asp containing peptides.

@article{Shin2004ModulationOD,
  title={Modulation of differentiation and mineralization of marrow stromal cells cultured on biomimetic hydrogels modified with Arg-Gly-Asp containing peptides.},
  author={Heungsoo Shin and Kyriacos Zygourakis and Mary C. Farach-Carson and Michael J. Yaszemski and Antonios G Mikos},
  journal={Journal of biomedical materials research. Part A},
  year={2004},
  volume={69 3},
  pages={535-43}
}
We synthesized biomimetic hydrogels modified with an osteopontin-derived peptide (ODP) and used them as a substrate for in vitro culture of marrow stromal cells (MSCs) to investigate the effect of the biomimetic surface on differentiation of MSCs into osteoblasts. Proliferation and biological assays for 16 days proved that MSCs became differentiated into osteoblasts secreting osteogenic phenotypic markers such as alkaline phosphatase (ALP), osteopontin, and mineralized calcium. In addition… CONTINUE READING
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