Modulation of diethylnitrosamine-initiated placental glutathione S-transferase positive preneoplastic and neoplastic lesions by clofibrate, a hepatic peroxisome proliferator.

@article{Hosokawa1989ModulationOD,
  title={Modulation of diethylnitrosamine-initiated placental glutathione S-transferase positive preneoplastic and neoplastic lesions by clofibrate, a hepatic peroxisome proliferator.},
  author={Satoru Hosokawa and Masae Tatematsu and Toyohiko Aoki and Jun‐ichi Nakanowatari and Takashi Igarashi and Nobuyuki Ito},
  journal={Carcinogenesis},
  year={1989},
  volume={10 12},
  pages={2237-41}
}
The effect of clofibrate (CF) on proliferation of diethylnitrosamine (DEN)-initiated glutathione S-transferase placental form (GST-P)-positive preneoplastic and neoplastic lesions as studied in male F344 rats. Animals were given a single i.p. injection of 200 mg/kg body weight of DEN, and then from 2 weeks later were given a diet containing 0.3% CF (group 1), or no supplement (group 2) until week 64. Group 3 received an injection of 0.9% NaCl instead of DEN and then a diet containing 0.3% CF… CONTINUE READING

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