Modulation of dendritic cell differentiation by HLA-G and ILT4 requires the IL-6--STAT3 signaling pathway.

@article{Liang2008ModulationOD,
  title={Modulation of dendritic cell differentiation by HLA-G and ILT4 requires the IL-6--STAT3 signaling pathway.},
  author={Siyuan Liang and Vladimir L Ristich and Hisashi Arase and Jean Dausset and Edgardo D. Carosella and Anatolij Horuzsko},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 24},
  pages={8357-62}
}
The expression of Ig-like transcript (ILT) inhibitory receptors is a characteristic of tolerogenic dendritic cells (DCs). However, the mechanisms of modulation of DCs via ILT receptors remain poorly defined. HLA-G is a preferential ligand for several ILTs. Recently, we demonstrated that triggering of ILT4 by HLA-G1 inhibits maturation of human monocyte-derived conventional DCs and murine DCs from ILT4 transgenic mice, resulting in diminished expression of MHC class II molecules, CD80 and CD86… CONTINUE READING

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