Modulation of dendritic AMPA receptor mRNA trafficking by RNA splicing and editing

@inproceedings{Via2013ModulationOD,
  title={Modulation of dendritic AMPA receptor mRNA trafficking by RNA splicing and editing},
  author={Luca La Via and Daniela Bonini and Isabella Russo and Cesare Orlandi and Sergio Barlati and Alessandro Barbon},
  booktitle={Nucleic acids research},
  year={2013}
}
RNA trafficking to dendrites and local translation are crucial processes for superior neuronal functions. To date, several α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor (AMPAR) mRNAs have been detected in dendrites and are subject to local protein synthesis. Here, we report the presence of all AMPAR GluA1-4 mRNAs in hippocampal and cortical rat synaptic spines by synaptoneurosomes analysis. In particular, we showed that dendritic AMPAR mRNAs are present in the Flip versions in the… CONTINUE READING
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