Modulation of cytokine responses of murine CD8+ alphabeta intestinal intraepithelial lymphocytes by IL-4 and IL-12.

@article{Gelfanova1999ModulationOC,
  title={Modulation of cytokine responses of murine CD8+ alphabeta intestinal intraepithelial lymphocytes by IL-4 and IL-12.},
  author={Valentina Gelfanova and Y G Lai and Vasily Gelfanov and S C Tzou and Yiping Tu and N S Liao},
  journal={Journal of biomedical science},
  year={1999},
  volume={6 4},
  pages={269-76}
}
The immune responses of the intestine mucosa feature the noninflammatory type, such as IgA production and oral tolerance. Th2 type cytokines have been implicated in the induction of these noninflammatory responses. In the present study, cytokine responses of CD8+ and CD4+ TCRalphabeta+ intestinal intraepithelial lymphocyte (alphabeta iIEL) subsets to TCR stimulation under the influence of IL-12, IL-4, or CD28 costimulation were examined. IL-12 enhanced production of IL-10 and IFN-gamma by the… CONTINUE READING
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