Modulation of cytokine release and neutrophil function by granulocyte colony-stimulating factor during endotoxemia in humans.

@article{Pajkrt1997ModulationOC,
  title={Modulation of cytokine release and neutrophil function by granulocyte colony-stimulating factor during endotoxemia in humans.},
  author={Dasja Pajkrt and A. Manten and Tom van der Poll and Monique M C Tiel-van Buul and J Jansen and J Wouter ten Cate and Sander J.H. van Deventer},
  journal={Blood},
  year={1997},
  volume={90 4},
  pages={1415-24}
}
In this double-blind, cross-over, placebo-controlled, randomized study, two groups of eight healthy male volunteers were challenged with endotoxin (4 ng/kg) on two occasions, once in conjunction with placebo and once with granulocyte colony-stimulating factor (G-CSF; 5 microg/kg). In group 1, G-CSF was administered intravenously 2 hours before endotoxin… CONTINUE READING