Modulation of cytokine production by Porphyromonas gingivalis in a macrophage and epithelial cell co-culture model.

@article{Bodet2005ModulationOC,
  title={Modulation of cytokine production by Porphyromonas gingivalis in a macrophage and epithelial cell co-culture model.},
  author={Charles Bodet and Fatiha Chandad and Daniel Grenier},
  journal={Microbes and infection},
  year={2005},
  volume={7 3},
  pages={448-56}
}
Epithelial cells and macrophages play a major role in the host response to Porphyromonas gingivalis, a major etiologic agent of chronic periodontitis. Secretion of high levels of cytokines by these cells is believed to contribute to periodontal tissue destruction. To investigate the interactions between P. gingivalis and these two major cell types, we characterized the production of interleukin-1beta (IL-1beta), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-alpha… CONTINUE READING
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