Modulation of cyclophosphamide-induced early lung injury by curcumin, an anti-inflammatory antioxidant

  title={Modulation of cyclophosphamide-induced early lung injury by curcumin, an anti-inflammatory antioxidant},
  author={N. E. Venkatesan and Gowri Chandrakasan},
  journal={Molecular and Cellular Biochemistry},
Cyclophosphamide causes lung injury in rats through its ability to generate free radicals with subsequent endothelial and epithelial cell damage. In order to observe the protective effects of a potent anti-inflammatory antioxidant, curcumin (diferuloyl methane) on cyclophosphamide-induced early lung injury, healthy pathogen free male Wistar rats were exposed to 20 mg/100 g body weight of cyclophosphamide, intraperitoneally as a single injection. Prior to cyclophosphamide intoxication oral… CONTINUE READING
Highly Cited
This paper has 66 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-10 of 29 extracted citations

Blueberry anthocyanins-enriched extracts attenuate the cyclophosphamide-induced lung toxicity.

Chemico-biological interactions • 2014
View 8 Excerpts
Highly Influenced

Curcumin-Role in Cancer

D. Nida Fathima

67 Citations

Citations per Year
Semantic Scholar estimates that this publication has 67 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 47 references

Chemoprotective effect of curcumin against cyclophosphamide toxicity

KK Soudamini, R Kuttan
Indian J Pharm Sci 54:213-217, • 1992
View 1 Excerpt

Suppressive effect ofcurcttmin on lipid pemxidation induced in rats by carbon tetrachlofide or 60 co-irradiation

I Nishigaki, R Kuttan, +3 authors K Yagi
J Clin Biochem Nutr • 1992
View 2 Excerpts

Metabolism and pulmonary toxicity of cyclophosphamide.

Pharmacology & therapeutics • 1990
View 1 Excerpt

Murlas CG: Guinea pig ozone-induced airway hyperreactivity is associated with increased N-acetyl-fI-D-glucosaminidase activity in bronchoalveolar lavage fluid

DB Lew, V Chodimella
View 1 Excerpt