Modulation of cyclooxygenase-2 activities by the combined action of celecoxib and decosahexaenoic acid: novel strategies for colon cancer prevention and treatment.

@article{Swamy2004ModulationOC,
  title={Modulation of cyclooxygenase-2 activities by the combined action of celecoxib and decosahexaenoic acid: novel strategies for colon cancer prevention and treatment.},
  author={M. Venakata Swamy and Indranie Cooma and Jagan M R Patlolla and Barbara Simi and B. Somasekhara Reddy and Chinthalapally V Rao},
  journal={Molecular cancer therapeutics},
  year={2004},
  volume={3 2},
  pages={215-21}
}
To develop efficient synergistic or additive combinations of chemopreventive and nutritional agents to reduce the risk of colon cancer, experiments were designed to test the application of a selective cyclooxygenase-2 (COX-2) inhibitor together with dietary omega-3 polyunsaturated fatty acids (PUFAs), such as decosahexaenoic acid (DHA). Thus, individual application of celecoxib, a COX-2 inhibitor, DHA, a omega-3 PUFA, and combinations of both were tested for their effectiveness using cell… CONTINUE READING