Modulation of connexin expression and gap junction communication in astrocytes by the gram-positive bacterium S. aureus.

Abstract

Gap junctions establish direct intercellular conduits between adjacent cells and are formed by the hexameric organization of protein subunits called connexins (Cx). It is unknown whether the proinflammatory milieu that ensues during CNS infection with S. aureus, one of the main etiologic agents of brain abscess in humans, is capable of eliciting regional… (More)

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