Modulation of connexin-43 by omega-3 fatty acids in the aorta of old spontaneously hypertensive rats.

@article{Dlugosov2009ModulationOC,
  title={Modulation of connexin-43 by omega-3 fatty acids in the aorta of old spontaneously hypertensive rats.},
  author={Katar{\'i}na Dlugosov{\'a} and L'udmila Okruhlicov{\'a} and Marcela Mitasikova and Ru{\vz}ena Sotn{\'i}kov{\'a} and Iveta Bernatova and Peter Weismann and J{\'a}n Slez{\'a}k and Narcis Tribulova},
  journal={Journal of physiology and pharmacology : an official journal of the Polish Physiological Society},
  year={2009},
  volume={60 3},
  pages={63-9}
}
Hypertension alters expression of connexin-43 (Cx43) in cardiovascular system. The aim of the study was to investigate the effect of omega-3 polyunsaturated fatty acids (30 mg/day for 2 months) on expression of Cx43 in the aorta of 1-year-old male spontaneously hypertensive rats (SHR). Spatial distribution and expression of Cx43 in aortic wall of SHR and age-matched Lewis rats were determined by immunofluorescent method and Western blot. NO synthase (NOS) activity and endothelium-dependent… CONTINUE READING