Modulation of cognition-specific cortical activity by gonadal steroids: a positron-emission tomography study in women.

@article{Berman1997ModulationOC,
  title={Modulation of cognition-specific cortical activity by gonadal steroids: a positron-emission tomography study in women.},
  author={Karen Faith Berman and Peter J. Schmidt and David R Rubinow and Merry A Danaceau and John Darrell Van Horn and Giuseppe Esposito and Jill Louise Ostrem and Daniel R. Weinberger},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 16},
  pages={8836-41}
}
There is considerable evidence from animal studies that gonadal steroid hormones modulate neuronal activity and affect behavior. To study this in humans directly, we used H215O positron-emission tomography to measure regional cerebral blood flow (rCBF) in young women during three pharmacologically controlled hormonal conditions spanning 4-5 months: ovarian suppression induced by the gonadotropin-releasing hormone agonist leuprolide acetate (Lupron), Lupron plus estradiol replacement, and Lupron… CONTINUE READING
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