Modulation of cocaine self-administration in the rat through D-3 dopamine receptors.

@article{Caine1993ModulationOC,
  title={Modulation of cocaine self-administration in the rat through D-3 dopamine receptors.},
  author={S. Barak Caine and George F. Koob},
  journal={Science},
  year={1993},
  volume={260 5115},
  pages={
          1814-6
        }
}
The reinforcing properties of cocaine are probably mediated by the mesocorticolimbic dopamine pathways in the central nervous system, but not all of the dopamine receptor subtypes involved in cocaine's reinforcing actions have been clearly identified. Recently, the D-3 receptor has been cloned, and its distribution in the brain has been found to be relatively restricted to limbic projections of the midbrain dopamine system. The D-3-selective compounds 7-hydroxy-N,N-di-n-propyl-2-aminotetralin… 
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