Modulation of cocaine and food self-administration by low- and high-efficacy D1 agonists in squirrel monkeys

@article{Platt2001ModulationOC,
  title={Modulation of cocaine and food self-administration by low- and high-efficacy D1 agonists in squirrel monkeys},
  author={Donna M. Platt and James K. Rowlett and Roger D. Spealman},
  journal={Psychopharmacology},
  year={2001},
  volume={157},
  pages={208-216}
}
Rationale: Dopamine D1 ligands have been proposed as candidate medications for cocaine abuse. Previous studies have shown that the ability of D1 ligands to modulate the behavioral effects of cocaine may depend on agonist efficacy. Objectives: This study investigated the role of agonist efficacy in the ability of D1 ligands to modulate the reinforcing effects of cocaine in monkeys. Methods: Squirrel monkeys trained to self-administer cocaine under a second-order schedule of reinforcement were… CONTINUE READING