Modulation of clusterin isoforms is associated with all-trans retinoic acid-induced proliferative arrest and apoptosis of intimal smooth muscle cells.

@article{Orlandi2005ModulationOC,
  title={Modulation of clusterin isoforms is associated with all-trans retinoic acid-induced proliferative arrest and apoptosis of intimal smooth muscle cells.},
  author={Augusto Orlandi and Sabina Pucci and Alessandro Ciucci and Flavia Pichiorri and Amedeo Ferlosio and Luigi Giusto Spagnoli},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2005},
  volume={25 2},
  pages={348-53}
}
OBJECTIVE Clusterin is a heterodimeric glycoprotein which is implicated in several biological processes. The nuclear (n-CLU) and cytoplasmic secreted (s-CLU) isoforms have recently been described, but their role is still unclear. The aim of this study is to investigate the expression of clusterin and its isoforms during proliferative arrest and apoptosis of vascular smooth muscle cells (SMCs). METHODS AND RESULTS Clusterin expression was evaluated by immunohistochemistry and Western blotting… CONTINUE READING

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