Modulation of cisplatin cytotoxicity and cisplatin-induced DNA cross-links in HepG2 cells by regulation of glutathione-related mechanisms.

@article{Zhang2001ModulationOC,
  title={Modulation of cisplatin cytotoxicity and cisplatin-induced DNA cross-links in HepG2 cells by regulation of glutathione-related mechanisms.},
  author={Kai Zhang and Melissa Chew and Er Bin Yang and Ka Pak Wong and Patrick Mack},
  journal={Molecular pharmacology},
  year={2001},
  volume={59 4},
  pages={837-43}
}
Glutathione (GSH), glutathione S-transferase (GST), and glutathione conjugate export pump (GS-X pump) have been shown to participate collectively in the detoxification of many anticancer drugs, including cisplatin. Identification and regulation of the rate-limiting step in the overall system for cisplatin detoxification is of crucial importance for… CONTINUE READING