Modulation of cholinergic systems by manganese.

  title={Modulation of cholinergic systems by manganese.},
  author={Yoram Finkelstein and Dejan M Milatovic and Michael Aschner},
  volume={28 5},
Information on changes in the central nervous system (CNS) cholinergic systems following exposure to manganese are considerably less extensive than that associated with other neurotransmitter systems. However, experimental and clinical evidence support the notion that cholinergic activity plays a key role in the pathophysiology of manganese-induced neurotoxicity. Manganese acts as a chemical stressor in cholinergic neurons in a region-specific manner causing breakdown of the cellular… CONTINUE READING