Modulation of cholinergic neurotransmission in canine airways by thromboxane mimetic U46619.

@article{Chung1985ModulationOC,
  title={Modulation of cholinergic neurotransmission in canine airways by thromboxane mimetic U46619.},
  author={Kian Fan Chung and Timothy W. Evans and P D Graf and Jay A. Nadel},
  journal={European journal of pharmacology},
  year={1985},
  volume={117 3},
  pages={373-5}
}
We studied the effect of a thromboxane A2-mimetic, U46619, on the contractile responses of canine bronchial smooth muscle to cholinergic stimulation in vitro. U46619 (3 X 10(-10) M), at a concentration that did not cause contraction, enhanced the effect of electrical field stimulation at all frequencies; histamine (10(-7) M) and prostaglandin F2 alpha (10(-7) M) did not. U46619 (3 X 10(-10) M) did not affect methacholine-induced contractions. U46619 may therefore increase the prejunctional… CONTINUE READING

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